Peptide Database

Peptide NameV30-SP-8

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC41H72N16O11

DescriptionStandard

        ELAAIRHR
    

Molecular Weight965.11 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.70

Charge Density (pH 7.0) 0.1155

GRAVY Index-0.47

Hydrophobic Moment 0.11

Boman Index-0.32

Instability Index32.83

Aliphatic Index 122.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 456.80

LogP -3.72

H-bond Donors 17.0

H-bond Acceptors 13.0

Rotatable Bonds 32.0

Heavy Atoms 68.0

Ring Count 1.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087628 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyVapC-activating peptide

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsThe Ⓧ (position: 1 and 8) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. The Ⓙ (position: 5) in sequence is B5 stapling amino acid. Note: B5 is α-dipentenyl alanine. Ⓧ (1) and Ⓙ (5), Ⓙ (5) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple respectively

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetMycobacterium smegmatis

Activity12.5-25.0 μM

MethodMIC50

PaperSung-Min Kang, Heejo Moon, Sang-Woo Han, Do-Hee Kim, Byeong Moon Kim, Bong-Jin Lee. Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides. ACS Chem Biol. 2020 Sep 18;15(9):2493-2498. Epub 2020 Sep 9. PMID32840352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32840352/

RECORD: Rec_0334806 VERIFIED: YES

Provenance & Taxonomy

OrganismMycobacterium tuberculosis [Bacterium]

FamilyProtein-derived peptide

Tax ID1773

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial

TargetMycobacterium tuberculosis (strain H37Rv)

RECORD: Rec_0369546 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyVapC-activating peptide

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsThe Ⓩ (position: 1) in sequence is R8 stapling amino acid. Note: R8 is (R)-octenyl alanine. The Ⓧ (position: 8) in sequence is (S)-pentenyl alanine. Ⓩ (1) and Ⓧ (8) are cross-linked by hydrocarbon stapling through a undec-4-enyl staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetMycobacterium smegmatis

Activity>25 μM

MethodMIC50

PaperSung-Min Kang, Heejo Moon, Sang-Woo Han, Do-Hee Kim, Byeong Moon Kim, Bong-Jin Lee. Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides. ACS Chem Biol. 2020 Sep 18;15(9):2493-2498. Epub 2020 Sep 9. PMID32840352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32840352/