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MYP_099687
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Basic Information
Vaby D
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C127H194N36O42S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCTCDPWPVCTRN
Physicochemical Analysis
3089.51 Da
4.37
-1.30
-1.59
-0.0432
-0.04
0.32
0.13
56.17
32.33
0.0667
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1211.68
-17.20
46.0
47.0
87.0
211.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008621 VERIFIED: YES
Provenance & Taxonomy
Viola abyssinica [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Cytotoxic
Human histiocytic lymphoma U-937/GTB
2.6 μM
IC50
PMID21434649;20558471 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21434649/
RECORD: Rec_0046495 VERIFIED: NO
Provenance & Taxonomy
Viola abyssinica [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0071559 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 23.3%, E 0.0%, T 40.0%, C 36.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0100614 VERIFIED: NO
Provenance & Taxonomy
Viola abyssinica [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0117587 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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