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MYP_099637
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Basic Information
Nigroain-B1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C89H147N29O24S3
Standard
Sequence
CVISAGWNHKIRCKLTGNC
Physicochemical Analysis
2103.49 Da
9.16
2.82
2.52
0.1482
0.03
0.37
0.02
11.57
82.11
0.0526
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
872.17
-9.67
34.0
31.0
69.0
145.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044179 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Rabbit erythrocytes
100 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19778602/ PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0117963 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923 or Staphylococcus aureus ATCC 43300
50 μM
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovitt
RECORD: Rec_0168399 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
13-19
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC43300
50 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0193578 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Nigroain
127021
Structure & Mods
Linear cysteine-rich peptide scaffold with intramolecular disulfide potential [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Mast cell degranulation Histamine releasing
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0236499 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Nigroain
127021
Structure & Mods
Linear cysteine-rich peptide scaffold with intramolecular disulfide potential [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
23.77 μM
MIC
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
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