Peptide Database

Peptide Namesynthetic peptide from alpha-gliadin

Function Ontology

Venom / Toxin ▸ General toxin ▸ Celiac toxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC59H97N17O18S2

DescriptionStandard

        PCMDVVLQQHNI
    

Molecular Weight1396.63 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.09

Charge Density (pH 7.0) -0.0803

GRAVY Index0.19

Hydrophobic Moment 0.24

Boman Index0.16

Instability Index129.62

Aliphatic Index 113.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 564.68

LogP -4.91

H-bond Donors 19.0

H-bond Acceptors 20.0

Rotatable Bonds 45.0

Heavy Atoms 96.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326242 VERIFIED: YES

Provenance & Taxonomy

OrganismTriticum aestivum [Plant]

FamilyGliadin-derived

Tax ID4565;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Celiac toxic

Targetgliadin-reactive enterocyte / calreticulin cross-reactivity assays

PaperKrupickova S., Tuckova L., Flegelove Z., Michalak M., Walters J. R. F., Whelan A., Harries J., Vencovsky J., Tlaskalova-Hogenova H.. Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised antigliadin antibodies of patients with coeliac disease. Gut, 1999, 44, 168-173. PMID9895374 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9895374/

RECORD: Rec_0395948 VERIFIED: YES