Peptide Database

Peptide NamesHR1a

Function Ontology

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length80 amino acids

Chemical FormulaC378H637N109O127

DescriptionStandard

        NQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLIT
    

Molecular Weight8740.76 Da

Isoelectric Point (pI)6.32

Net Charge (pH 7.0)-0.23

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0029

GRAVY Index-0.18

Hydrophobic Moment 0.71

Boman Index-0.01

Instability Index28.76

Aliphatic Index 113.38

Aromaticity 0.0250

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3936.06

LogP -49.15

H-bond Donors 131.0

H-bond Acceptors 127.0

Rotatable Bonds 308.0

Heavy Atoms 614.0

Ring Count 2.0

Amide Bonds 97.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349901 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyVirus-derived peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetSARS coronavirus (Fusion); Vero

Activity50 μM

MethodEC50

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/

RECORD: Rec_0375356 VERIFIED: YES