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MYP_099572
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Basic Information
Varv He
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
30 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLPVCGETCFGGTCNTPGCSCXTWPVCSRN
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250799 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant],Viola tricolor [Plant]
Varv peptide H
214053
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
X at 22 (reported unspecified residue)
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0282351 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant],Viola tricolor [Plant]
Varv peptide H
214053
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
X at 22 (reported unspecified residue)
Bio-Activity Profile
Anticancer Cytotoxic
Human breast adenocarcinoma MDA-MB-231
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0289906 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Glu-ethylation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0308688 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
5-19, 9-21, 14-27
cyclic peptide, E22: ethylated
Bio-Activity Profile
Antimicrobial Antitumor
RECORD: Rec_0351170 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant],Viola tricolor [Plant]
Varv peptide H
214053
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
X at 22 (reported unspecified residue)
Bio-Activity Profile
Anticancer Cytotoxic
Human prostate cancer DU145
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
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