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MYP_099572
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Basic Information
Varv He
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
30 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLPVCGETCFGGTCNTPGCSCXTWPVCSRN
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074754 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Glu-ethylation
Bio-Activity Profile
Antimicrobial Anticancer
BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0114566 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Glu-methylation
Bio-Activity Profile
Antimicrobial Anticancer
BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0154349 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant],Viola tricolor [Plant]
Varv peptide H
214053
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
X at 22 (reported unspecified residue)
Bio-Activity Profile
Anticancer Cytotoxic
Human hepatocarcinoma BEL-7402
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0195591 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant],Viola tricolor [Plant]
Varv peptide H
214053
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
X at 22 (reported unspecified residue)
Bio-Activity Profile
Anticancer Cytotoxic
Human glioblastoma U251-MG
55.43 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0223742 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Glu-methylation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
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