Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length188 amino acids

Chemical FormulaC932H1476N260O245S9

DescriptionStandard

        PTVLPAAHEPMLLLAITEFVANSAAFAYFTAGALRRNISSNMLPRRFPLQLRTKSMGVFSPQLQERYPDQPMELHLSARRQPLLSCHPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTPCLRRGPLCLPHAGLKGLPVPQVKRLETLLKFGLWLFGVPWANSECCPHPVP
    

Molecular Weight20531.87 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)8.45

Net Charge (pH 7.4) 7.99

Charge Density (pH 7.0) 0.0449

GRAVY Index0.09

Hydrophobic Moment 0.57

Boman Index0.12

Instability Index64.35

Aliphatic Index 95.53

Aromaticity 0.0745

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7866.22

LogP -90.38

H-bond Donors 271.0

H-bond Acceptors 268.0

Rotatable Bonds 641.0

Heavy Atoms 1446.0

Ring Count 44.0

Amide Bonds 201.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0202166 VERIFIED: YES

Provenance & Taxonomy

OrganismEudyptula [Animal]

Tax ID37082

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

RECORD: Rec_0247970 VERIFIED: NO