Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length513 amino acids

Chemical FormulaC2601H4055N645O752S20

DescriptionStandard

        MLPRLEMRTKAVQVLWGCFFLWNLCSSSTQTIYPGIKARVTQRALDYGIQAGMEMIEQMIKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGEADLFLSGVYFTGIIVLSQNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPLDNLTDPPFLPVPFALPERSDSMLYVGISEFFFKSASFAYFIAGAFNVTLSMKEISNHLVQNSQGLGNMLSRIAEIYILSQPFMVRVMATEPPVISLLPGNFTLDIPASIVILTQPENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESSRSNIEVLRFENILSSILHFGILPLANAKLQQGIPLPNPHKISFVNSDVEVFEGFLLISTDLKYETSLKQQPSFHGWEGLSLMSGQWRGKPAA
    

Molecular Weight57034.19 Da

Isoelectric Point (pI)5.11

Net Charge (pH 7.0)-13.78

Net Charge (pH 7.4) -14.59

Charge Density (pH 7.0) -0.0269

GRAVY Index0.18

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index37.11

Aliphatic Index 103.74

Aromaticity 0.1014

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0391194 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyBPI/LBP

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence