Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length180 amino acids

Chemical FormulaC897H1444N258O236S6

DescriptionStandard

        PTALPAAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSNMLPRRFPLQLRTKSLGLFSPQLQERYPDQPMELRLSARRQPLLSCRPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTPCLRRGRLCLPRAGLRALPVPQVKRLETLLKFGLWLFGVPWANS
    

Molecular Weight19811.04 Da

Isoelectric Point (pI)11.35

Net Charge (pH 7.0)13.12

Net Charge (pH 7.4) 12.89

Charge Density (pH 7.0) 0.0729

GRAVY Index0.05

Hydrophobic Moment 0.60

Boman Index0.06

Instability Index61.82

Aliphatic Index 99.28

Aromaticity 0.0778

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7820.27

LogP -88.01

H-bond Donors 275.0

H-bond Acceptors 257.0

Rotatable Bonds 630.0

Heavy Atoms 1397.0

Ring Count 36.0

Amide Bonds 193.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0296846 VERIFIED: NO

Provenance & Taxonomy

OrganismMesembrinibis cayennensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria