Peptide Database

Peptide NamePB1-1-15 A T6C

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC77H126N18O20S2

DescriptionStandard

        MDVNPCLLFLKVPAQ
    

Molecular Weight1688.06 Da

Isoelectric Point (pI)5.59

Net Charge (pH 7.0)-0.51

Net Charge (pH 7.4) -0.74

Charge Density (pH 7.0) -0.0340

GRAVY Index0.75

Hydrophobic Moment 0.25

Boman Index0.29

Instability Index29.59

Aliphatic Index 123.33

Aromaticity 0.0667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 602.64

LogP -2.66

H-bond Donors 19.0

H-bond Acceptors 22.0

Rotatable Bonds 52.0

Heavy Atoms 117.0

Ring Count 3.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0002552 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Anti-influenza A Anti-influenza B PA-binding inhibitor Polymerase inhibition Replication inhibition

TargetInfluenza A virus; MDCK cells

Activity0.04358±0.00567 μM

MethodIC50 (PA-binding/polymerase and virus-replication inhibition)

RECORD: Rec_0055642 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct derived from Influenza A virus PB1 [Synthetic]

FamilyVirus-derived peptide

Tax ID11320;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsSequence-variant derivative

Bio-Activity Profile

Function

Antiviral Replication inhibitor Anti-influenza A Anti-influenza B PA-binding inhibitor Polymerase inhibition Replication inhibition

TargetInfluenza A virus; MDCK cells

Activity0.04358 μM

MethodIC50 (PA-binding/polymerase and virus-replication inhibition)

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Manz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/

RECORD: Rec_0061397 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Replication inhibition Anti-influenza A Anti-influenza B PA-binding inhibitor Polymerase inhibition

TargetInfluenza A virus; MDCK cells

Activity0.04358±0.00567 μM

MethodIC50 (PA-binding/polymerase and virus-replication inhibition)

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Mänz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 Oct 20;4(10):e7517. | DOI:10.1371/journal.pone.0007517 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/

RECORD: Rec_0122063 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Anti-influenza A Anti-influenza B PA-binding inhibitor Polymerase inhibition Replication inhibition

TargetInfluenza B virus; MDCK cells

Activity3 μM

MethodIC50 (PA-binding/polymerase and virus-replication inhibition)

RECORD: Rec_0123626 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Anti-influenza A Anti-influenza B PA-binding inhibitor Polymerase inhibition Replication inhibition

TargetInfluenza A and B viruses

MethodPA-binding/polymerase and virus-replication inhibition assays

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