Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length454 amino acids

Chemical FormulaC2289H3575N603O642S9

DescriptionStandard

        TDPGFVVRITQAGLDYAHQQGIAILEKELAQLKLPDISGDFRIQHVGKVNYEISRLDLRSFHLPYSRISLVPGVGLQVSISNAFAEVDGNWRVKLYFIRDHGSFDLKVENVYIKIKLKLGSDASGKPTIDTSDCSTRISKVRVHFQGKFGWLYNLFYSAVESRFRNILESKVCENVVTSVRSELQPYLQTLPVTARIDDKAGIDYSLVALPTATAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFAASSYFFNTAGFAYHAAGALVFEITESMIPKSIGFHLNTSTFSAFIPQLEKMYPDMPVKLRLSAPSAPFLNIGPGGLSLKPVVDIQAYAILPSSSLAPLFLLSLTSNVSAVIDVKFGHIVGSLNMGRYGAGAAQGSARTVRMLQSLMNTIASTVLLPHLNERLDEGFPLPLPDRIQLSNILVRFHQNFLLLGADVHYQPR
    

Molecular Weight50102.11 Da

Isoelectric Point (pI)8.63

Net Charge (pH 7.0)3.55

Net Charge (pH 7.4) 2.57

Charge Density (pH 7.0) 0.0078

GRAVY Index0.11

Hydrophobic Moment 0.70

Boman Index0.13

Instability Index35.70

Aliphatic Index 101.81

Aromaticity 0.1013

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 34965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382745 VERIFIED: NO

Provenance & Taxonomy

OrganismPandion haliaetus (Osprey) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria