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MYP_099393
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Basic Information
ZIKV Ep (424-452)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Standard
29 amino acids
C142H208N36O37
Standard
Sequence
AWDFGSVGGVFNSLGKGIHQIFGAAFKSL
Physicochemical Analysis
3011.39 Da
8.64
0.88
0.64
0.0304
0.50
0.68
0.38
-4.26
84.14
0.1724
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1158.80
-10.17
40.0
39.0
97.0
215.0
7.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Zika virus (ZIKV) H/PF
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0080506 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Zika virus (ZIKV) MRS
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0093995 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Zika virus (ZIKV)
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0297771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-ZIKV Entry inhibition
Zika virus (ZIKV) | Vero cells
1.32 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0417199 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Zika virus (ZIKV):inhibition of Zika virus (ZIKV) infection in Vero cells
1.32 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/