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MYP_099321
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Basic Information
Cyclic Tachyplesin-3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
18 amino acids
C101H157N33O21S4
Standard
Sequence
KWCFRVCYRGICYRKCRG
Physicochemical Analysis
2297.80 Da
9.79
5.72
5.45
0.3176
-0.48
0.65
-0.33
-23.49
37.78
0.2222
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
913.91
-6.50
40.0
31.0
74.0
159.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016214 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tachyplesin
32630
Structure & Mods
backbone-cyclized disulfide-stabilized beta-hairpin [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Cytotoxicity testing Hemolysis testing Membrane-disruptive
Gram-negative and Gram-positive bacteria; melanoma cell lines; human red blood cells
qualitative summary of MIC, cancer-cell cytotoxicity, HC50/hemolysis, serum-stability and membrane-interaction assays
PaperCharacterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. Int J Mol Sci. 2019;20:4184. PMID:31455019; DOI:10.3390/ijms20174184 PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0047874 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
8 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0223170 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DC2 CGSC 7139
1-2 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0261165 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
2-8 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0289902 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
4-8 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
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