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MYP_099304
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Basic Information
IN(1-10)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
10 amino acids
C53H83N17O14S
Standard
Sequence
WQCLTLTHRG
Physicochemical Analysis
1214.40 Da
8.26
0.84
0.57
0.0837
-0.38
0.36
-0.02
12.23
78.00
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
515.14
-4.60
20.0
17.0
37.0
85.0
3.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016127 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of virus replication in TZM-bl cells
62.5 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. | Maes M, Levin A, Hayouka Z, Shalev DE, Loyter A, Friedler A. | Bioorg Med Chem. 2009 Nov 15;17(22):7635-42. | DOI:10.1016/j.bmc.2009.09.053 | PMID:19850483 PMID19850483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19850483/
RECORD: Rec_0026528 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of integrase catalytic activity
73 %
Inhibition
PaperPubMed PMID: 19850483 PMID19850483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19850483/
RECORD: Rec_0033798 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of intergration
62.5 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. | Maes M, Levin A, Hayouka Z, Shalev DE, Loyter A, Friedler A. | Bioorg Med Chem. 2009 Nov 15;17(22):7635-42. | DOI:10.1016/j.bmc.2009.09.053 | PMID:19850483 PMID19850483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19850483/
RECORD: Rec_0055901 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
62.5 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. | Maes M, Levin A, Hayouka Z, Shalev DE, Loyter A, Friedler A. | Bioorg Med Chem. 2009 Nov 15;17(22):7635-42. | DOI:10.1016/j.bmc.2009.09.053 | PMID:19850483 PMID19850483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19850483/
RECORD: Rec_0077237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[60-70% REP = 62.5 microM]
PMID19850483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19850483/
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