Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length141 amino acids

Chemical FormulaC701H1125N197O192S6

DescriptionStandard

        PMALATVHEPMLLLAITEFVANSAAFTYFTAGALERNISSDMLPRRFPLQLKTKSMGLFSPQLQERYPDHPMELRLSARRQPRLFCRPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPIITRNRLGGTVSLKG
    

Molecular Weight15577.03 Da

Isoelectric Point (pI)10.25

Net Charge (pH 7.0)6.23

Net Charge (pH 7.4) 5.98

Charge Density (pH 7.0) 0.0442

GRAVY Index0.05

Hydrophobic Moment 0.82

Boman Index0.07

Instability Index45.72

Aliphatic Index 94.89

Aromaticity 0.0780

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6168.06

LogP -57.15

H-bond Donors 215.0

H-bond Acceptors 207.0

Rotatable Bonds 503.0

Heavy Atoms 1096.0

Ring Count 26.0

Amide Bonds 150.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0332423 VERIFIED: NO

Provenance & Taxonomy

OrganismRissa tridactyla (Black-legged kittiwake) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria