Peptide Database

Peptide NameC-type natriuretic peptide

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC185H305N57O51S2

DescriptionStandard

        LLHDHPNPRKYKPANKKGLSKGCFGLKLDRIGSTSGLGC
    

Molecular Weight4207.88 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.91

Net Charge (pH 7.4) 5.57

Charge Density (pH 7.0) 0.1515

GRAVY Index-0.71

Hydrophobic Moment 0.49

Boman Index-0.13

Instability Index4.77

Aliphatic Index 72.56

Aromaticity 0.0513

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1741.96

LogP -19.19

H-bond Donors 62.0

H-bond Acceptors 61.0

Rotatable Bonds 142.0

Heavy Atoms 295.0

Ring Count 7.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0269936 VERIFIED: NO

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0316458 VERIFIED: YES

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyC-type natriuretic peptide

Tax ID9258

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other Mods2:D-leucine

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Receptor modulation

TargetIMR-32 human neuroblastoma cells

Half-LifeMammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0316892 VERIFIED: YES

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyC-type natriuretic peptide

Tax ID9258

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other Mods2:D-leucine

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Receptor modulation

Half-LifeMammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0385413 VERIFIED: YES

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyC-type natriuretic peptide

Tax ID9258

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other Mods2:D-leucine

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Receptor modulation

Targetrat aortic smooth muscle cells

Half-LifeMammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min