Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length399 amino acids

Chemical FormulaC1941H3081N495O569S14

DescriptionStandard

        MAMWWLLHLLVLSPLSLCTNPGITVRLTQKGLEYGRQIGIAVLQQKLKSVHIPDISGKESVSPVGSVEYSLSGMQVVSLGLPQSSLVLTPGSGLSLSIGNAYISIDGNWRVKYLKFIKDHGSFDLSVSELSISAVMAVSSDETGRPTVSCTSCSASVGSAKIKFHGGASWLYNLFSSFIDKALRKALQDKLCPLVTDAIAGINPHLKTLNVLAKVDQYAEIEYSMVSSPVITKDYIDLNLKGEFYNIGKHQEPPFPAPGFSMPAQANSMLYFGVSQFTPNSAGFVYSTTGVLSINVTDNMIPKTSPLRLSTKTFGAFIPEIAKRYPGLQMELLVKSTKQPFVTFQTNNMTLQAVGSITAYAIQPNSTLTPLFVLGLDASVSGNVYVSGVKVAGSLSLNR
    

Molecular Weight42904.11 Da

Isoelectric Point (pI)9.07

Net Charge (pH 7.0)6.99

Net Charge (pH 7.4) 6.33

Charge Density (pH 7.0) 0.0175

GRAVY Index0.18

Hydrophobic Moment 0.75

Boman Index0.18

Instability Index36.34

Aliphatic Index 99.40

Aromaticity 0.0852

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344436 VERIFIED: NO

Provenance & Taxonomy

OrganismAtractosteus spatula [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence