Peptide Database

Peptide NameBrevinin-2GHb (AMP-2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC339H566N92O107S6

DescriptionStandard

        MFTMKKSLLLLFFLGTVSLSLCEQERGADEDDGGEMTEELKRGVITDALKGAAKTVAAELLRKAHCKLTNSC
    

Molecular Weight7835.06 Da

Isoelectric Point (pI)5.75

Net Charge (pH 7.0)-1.43

Net Charge (pH 7.4) -1.76

Charge Density (pH 7.0) -0.0198

GRAVY Index-0.03

Hydrophobic Moment 0.59

Boman Index0.01

Instability Index22.03

Aliphatic Index 92.22

Aromaticity 0.0417

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3224.72

LogP -31.90

H-bond Donors 116.0

H-bond Acceptors 113.0

Rotatable Bonds 276.0

Heavy Atoms 544.0

Ring Count 4.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152792 VERIFIED: YES

Provenance & Taxonomy

OrganismSylvirana guentheri [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0248671 VERIFIED: YES

Provenance & Taxonomy

OrganismSylvirana guentheri [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0340967 VERIFIED: YES

Provenance & Taxonomy

OrganismSylvirana guentheri [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus subtilis (Gram-positive)