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MYP_099138
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Basic Information
EBR28[L3A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
12 amino acids
C71H116N18O17S
Standard
Sequence
YQALIRMIYKNI
Physicochemical Analysis
1525.86 Da
9.70
1.76
1.55
0.1464
0.25
0.65
0.11
45.78
138.33
0.1667
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
597.98
-1.88
21.0
20.0
51.0
107.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
HIV-1; P4 cells
no inhibition
HIV-1 infection inhibition assay up to 100 μM
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0064303 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
HIV-1 integrase
165 μM
IC50 (HIV-1 integrase 3′-end processing inhibition)
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase. PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0100289 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1
no inhibition
HIV-1 infection inhibition assay up to 100 μM
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0151761 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0170520 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1 integrase
165 μM
IC50 (HIV-1 integrase 3′-end processing inhibition)
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase. | de Soultrait VR, Caumont A, Parissi V, Morellet N, Ventura M, Lenoir C, Litvak S, Fournier M, Roques B. | J Mol Biol. 2002 Apr 19;318(1):45-58. | DOI:10.1016/S0022-2836(02)00033-5 | PMID:12054767 PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
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