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MYP_099126
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Basic Information
Alloferon-1 [H1K]
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
13 amino acids
C52H81N21O16
Standard
Sequence
KGVSGHGQHGVHG
Physicochemical Analysis
1256.33 Da
8.77
1.02
0.66
0.0785
-0.88
0.33
0.06
-21.23
44.62
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
587.90
-9.03
20.0
20.0
41.0
89.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Coxsackievirus B2 strain 971 PT
antiviral cytopathic-effect assay
PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0019067 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
Coxsackievirus B2 strain 971 PT; LLC-MK2 cells
157.7 μg/mL
IC50 (antiviral cytopathic-effect assay)
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperFurther studies on the antiviral activity of alloferon and its analogues. | Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D. | J Pept Sci. 2011 Nov;17(11):715-9. | DOI:10.1002/psc.1388 | PMID:21766388 PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0069792 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Coxsackievirus B2; LLC-MK2 cells
190.67 μg/mL
IC50 (antiviral cytopathic-effect assay)
PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0071482 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic Non-cytotoxic
Vero cells
no cytotoxicity
cytotoxicity assay up to 218.75 μg/mL
PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0162992 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Coxsackievirus B2 strain 971 PT; HEp-2 cells
107.04 μg/mL
IC50 (antiviral cytopathic-effect assay)
PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
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