Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2441H3841N661O697S9

DescriptionStandard

        MMARPSSVVLALLLLAEVSGFAEGASNPGFVARITRKGLEYAHRYGIATLKKELSTIKLPDFSGSFKVGWIKSVSYEFYRLKIHRFELRNSDLRLRPTQGITASLSNNYVAVSGNWKVKKAFITLDGTFDVRVDGISISVSLNLGKDQSGRPTASVAHCSNSIGHVSIDISGSLSWILNLFHKRIENNFKNILEQKICEMVRKSTASHLEPYLRTLPVIAMIDQVAGIDYSLVGAPQVTSQVIDTPFKGEFFGRNWRSPAPFNAPPIRLPEKQDHSVYFAVSEHVFNTASRVYHQAGRMNFTIQNQHIPLDSPIHLHTNSFRAIIPQLARLYPNTELELETSPESAPFLMFTPGNVTLSPVIDIQAFALLPTSSERKLLFELRVTTNISATISVSSGRIVGSVTTGSKLKLELKHSNVRYFNVDLMEAILNYYALHTLYPSLNAKLEEGFPLPLPRDTYLNSLELHVHKNFLLLGANLEEAEH
    

Molecular Weight53888.20 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)8.02

Net Charge (pH 7.4) 6.80

Charge Density (pH 7.0) 0.0166

GRAVY Index-0.07

Hydrophobic Moment 0.75

Boman Index0.08

Instability Index31.35

Aliphatic Index 98.51

Aromaticity 0.0911

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389511 VERIFIED: NO

Provenance & Taxonomy

OrganismPanthera pardus (Leopard) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria