Peptide Database

Peptide NameEpilancin K7

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC136H240N38O42S3

DescriptionStandard

        SASVLKTSIKVSKKYCKGVTLTCGCNITGGK
    

Molecular Weight3175.78 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)5.42

Net Charge (pH 7.4) 5.16

Charge Density (pH 7.0) 0.1750

GRAVY Index0.09

Hydrophobic Moment 0.60

Boman Index0.04

Instability Index8.66

Aliphatic Index 81.61

Aromaticity 0.0323

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1317.60

LogP -17.48

H-bond Donors 51.0

H-bond Acceptors 51.0

Rotatable Bonds 111.0

Heavy Atoms 219.0

Ring Count 1.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063542 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus epidermidis K7 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

RECORD: Rec_0233394 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus epidermidis [Bacterium]

FamilyBacteriocin

Tax ID1282

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

RECORD: Rec_0255197 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

RECORD: Rec_0311365 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus epidermidis [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsResidue S1 has been modified into Hop (2-hydroxypropionyl, a new modification found then), While S3, T7, S8, and T28 are dehydrated. In addition, there is one lanthionine S12-C16 and two methyl-lanthionines T20-C23 and T22-C25. Updated Jan 2013

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0418602 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus epidermidis [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)