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MYP_099000
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Basic Information
Phylloseptin-1 (PS-1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C93H150N26O24
Standard
Sequence
FLSLIPHAINAVSAIAKHN
Physicochemical Analysis
2016.35 Da
8.76
0.93
0.63
0.0491
0.78
0.48
0.36
20.42
138.95
0.0526
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
788.35
-6.36
26.0
27.0
63.0
143.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0319260 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
7.9 μM
MIC
PaperJ.R.S.A. Leite et al. / Peptides 26 (2005) 565-573. Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus Evidence URLhttps://www.uniprot.org/uniprotkb/P84566/entry
RECORD: Rec_0324068 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Psecdomonas aeruginosa
4 μM
MIC
PMID15752569;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0344051 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania amazonensis MHOM/BR/pH8
64 μg/mL
Percent inhibition; Microscopy (Phase-contrast)
PMID19460376 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19460376/
RECORD: Rec_0373484 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0390661 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
4 μM
MIC
PMID15752569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
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