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MYP_099000
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Basic Information
Phylloseptin-1 (PS-1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C93H150N26O24
Standard
Sequence
FLSLIPHAINAVSAIAKHN
Physicochemical Analysis
2016.35 Da
8.76
0.93
0.63
0.0491
0.78
0.48
0.36
20.42
138.95
0.0526
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
788.35
-6.36
26.0
27.0
63.0
143.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242031 VERIFIED: YES
Provenance & Taxonomy
Brazilian tree [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15648972 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15648972/
RECORD: Rec_0244913 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
7.9 μM
MIC
PMID15752569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0297831 VERIFIED: YES
Provenance & Taxonomy
Phylllomedusa hypochondrialis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Enterococcus faecalis ATCC
4.0 μM
MIC
PaperPhylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
RECORD: Rec_0303041 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
frog skin active peptide (FSAP) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial frog skin active peptide (FSAP) family Antibacterial Host defense
PaperPDB 2JQ0 structural record; NMR; chain A; residues 1-19
RECORD: Rec_0312522 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Staphylococcus aureus
7.9 μM
MIC
PMID15752569;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
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