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MYP_099000
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Basic Information
Phylloseptin-1 (PS-1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C93H150N26O24
Standard
Sequence
FLSLIPHAINAVSAIAKHN
Physicochemical Analysis
2016.35 Da
8.76
0.93
0.63
0.0491
0.78
0.48
0.36
20.42
138.95
0.0526
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
788.35
-6.36
26.0
27.0
63.0
143.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177579 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
7.9 μM
MIC
PaperJ.R.S.A. Leite et al. / Peptides 26 (2005) 565-573. Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus Evidence URLhttps://www.uniprot.org/uniprotkb/P84566/entry
RECORD: Rec_0203762 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 73.7%, E 0.0%, T 10.5%, C 15.8% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Antiplasmodial Hemolytic Anti-Gram-positive Antileishmanial Antiprotozoal
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0209444 VERIFIED: YES
Provenance & Taxonomy
Phylllomedusa hypochondrialis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Escherichia coli ATCC
7.9 μM
MIC
PaperPhylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
RECORD: Rec_0216865 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic
Escherichia coli
PMID15752569;18644413;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0239762 VERIFIED: YES
Provenance & Taxonomy
Phylllomedusa hypochondrialis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Pseudomonas aeruginosa
3-4 μM
MIC
PaperPhylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
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