Peptide Database

Peptide NameHirulog-1

Function Ontology

Hemostasis ▸ Anticoagulant activity

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H140N24O33

DescriptionStandard

        FPRPGGGGQGDFEEIPEEYL
    

Molecular Weight2194.31 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.23

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.2114

GRAVY Index-0.98

Hydrophobic Moment 0.36

Boman Index0.03

Instability Index89.21

Aliphatic Index 39.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 901.57

LogP -7.73

H-bond Donors 28.0

H-bond Acceptors 29.0

Rotatable Bonds 67.0

Heavy Atoms 156.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0182621 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyHirudin

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Other ModsD-residue notation at positions 1; Mixed L/D stereochemistry with D-annotated positions 1

Bio-Activity Profile

Function

Anticoagulant

Activity0.0205±0.00062 μM

MethodKi

Half-LifeSprague-Dawley (SD) rats plasma (Dose i/v injected), in vivo; 900 s