Peptide Database

Peptide NameDEF1_CAPAN

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length75 amino acids

Chemical FormulaC351H564N94O100S13

DescriptionStandard

        CRREGFTDGSCIGFRLQCFCTKPCAMAGFSKVVATIFLMMLLVFATDMMAEAKICEALSGNFKGLCLSSRDCGNV
    

Molecular Weight8117.65 Da

Isoelectric Point (pI)8.20

Net Charge (pH 7.0)1.69

Net Charge (pH 7.4) 1.36

Charge Density (pH 7.0) 0.0225

GRAVY Index0.56

Hydrophobic Moment 0.48

Boman Index0.17

Instability Index28.09

Aliphatic Index 76.80

Aromaticity 0.0933

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3094.75

LogP -30.58

H-bond Donors 117.0

H-bond Acceptors 115.0

Rotatable Bonds 272.0

Heavy Atoms 558.0

Ring Count 8.0

Amide Bonds 77.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082671 VERIFIED: YES

Provenance & Taxonomy

OrganismCapsicum annuum [Plant]

FamilyDefensin

Tax ID4072

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Signaling Enzyme inhibitory ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme