‹ ›
MYP_098967
← PREVIOUS NEXT → BACK
Basic Information
All-D-Magainin-2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
23 amino acids
C114H180N30O29S
Standard
Sequence
GIGKFLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
2466.90 Da
10.00
2.85
2.59
0.1237
0.08
0.69
0.17
-0.10
72.17
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
957.13
-7.89
33.0
34.0
86.0
174.0
4.0
23.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0397980 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Not included yet
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
RT4(G1)
135.3 M
Cell viability assay
PaperAntitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines PMID16476519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16476519/
RECORD: Rec_0399729 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]; Xenopus petersii [Animal]; Xenopus victorianus [Animal]; Xenopus laevis sudanesis [Animal]; Xenopus ruwenzoriensis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiviral Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
125-250 μg/mL
MIC
PaperZasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987;84(15):5449-5453.; Antimicrobial peptides in the stomach of Xenopus laevis.; The effects of magainin 2-derived and rationally designed antimicrobial peptides on Mycoplasma pneumoniae. PMID1717472;3299384;35073323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
RECORD: Rec_0401316 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
100 μM
Percent inhibition; Microscopy (2% mercurochrome staining oocyst growth examined)
PaperAntimicrobial peptide action on parasites PMID22664071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22664071/
RECORD: Rec_0401876 VERIFIED: YES
Provenance & Taxonomy
Xenopus ruwenzoriensis [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Escherichia coli D31
5 μg/mL
MIC
PMID3299384;9090128 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3299384/
RECORD: Rec_0406744 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DH5α
3.125 μM
MIC
PMID31667994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31667994/
FIRST PREV 1 ... 39 40 41 42 43 NEXT LAST
Showing 5 records · Page 41 of 43