MYP_098967
All-D-Magainin-2
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
▸
Cytotoxic
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-negative
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
▸
Antibacterial
▸
Anti-Mycobacterium
Antimicrobial
▸
Anti-biofilm
▸
Biofilm inhibition
Antimicrobial
▸
Antifungal
Antiparasitic
▸
Antimalarial
Antiparasitic
▸
Antiprotozoal
Antiparasitic
▸
Antiprotozoal
▸
Antimalarial
▸
Anti-Plasmodium
Antiparasitic
▸
Antiprotozoal
▸
Anti-Trypanosoma
Antiparasitic
▸
General antiparasitic
▸
Antiparasitic
Antiviral
▸
Anti-Herpesvirus
▸
Antiviral
▸
Antiviral mechanism
▸
Antiviral
▸
Antiviral mechanism
▸
Viral replication inhibition
▸
Antiviral
▸
Immunology
▸
Immune modulation
▸
Immunomodulatory activity
Immunology
▸
Innate immune defense
▸
Host defense peptide
▸
Defense peptide
Immunology
▸
Innate immune defense
▸
Host defense peptide
▸
Host defense activity
Insecticidal/Pest control
▸
Insecticidal activity
Reproductive biology
▸
Contraceptive activity
▸
Spermicidal
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytolysis / cell lysis
▸
Cytolytic activity
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Toxicity / Safety
▸
Negative safety assay result
▸
Non-hemolytic
Venom / Toxin
▸
General toxin
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Toxic
Wound healing/Regeneration
▸
Wound healing
Standard
23 amino acids
C114H180N30O29S
Standard
GIGKFLHSAKKFGKAFVGEIMNS
2466.90 Da
10.00
2.85
2.59
0.1237
0.08
0.69
0.17
-0.10
72.17
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
957.13
-7.89
33.0
34.0
86.0
174.0
4.0
23.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0104101
VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Antiparasitic
Antiprotozoal
Anti-Gram-positive
Anti-Gram-negative
[ Refer PubMed : 3299384 :- Escherichia coli D31 (
500 μg/mL
MIC
RECORD: Rec_0104672
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 7 and 11) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. The J (position: 21) in sequence is norlercine. Ⓧ (7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 25923
25.00 μg/mL
MIC
RECORD: Rec_0109089
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 10) in sequence is S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. The Ⓩ (position: 3) in sequence is R8 stapling amino acid. Note: R8 is (R)-octenyl alanine. The J (position: 21) in sequence is norlercine. Ⓧ (10) and Ⓩ (3) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
Antibacterial
Bacillus cereus ATCC 14579
8.84 μg/mL
MIC
RECORD: Rec_0111410
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 13 and 17) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. The J (position: 21) in sequence is norlercine. Ⓧ (13) and Ⓧ (17) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
Antibacterial
Pseudomonas aeruginosa ATCC 27853
4.42 μg/mL
MIC
RECORD: Rec_0113053
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 21) in sequence is S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. The Ⓩ (position: 14) in sequence is R8 stapling amino acid. Note: R8 is (R)-octenyl alanine. Ⓧ (21) and Ⓩ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
Antibacterial
Escherichia coli ATCC 25922
2.21 μg/mL
MIC
Showing 5 records on this page · Page 17 of 64