Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length409 amino acids

Chemical FormulaC2073H3239N513O603S17

DescriptionStandard

        MHTKMVQVLWGCLLLCNLYISSTETIYPGIKARATKRALDYGVQAGMEIIEQMVKERNISDLKGSESLEFLKIDYVNYNFTNIKITAFSFPNTSLAFVPGVGIRALTNHGIANISTDWDIKSPLFQDTGGADLFLSEVYFTGILILSRNNFGHPVLKLQDCYAQVSHADVSFSGEFSVLYNSFAEPMEKPILKNLNEMLCPIIIHEVEALNANLSMLQFFTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPQENLADPPFPSVPFVLPERSDSMLYIGISKYFFKSASYAYFTAGAFGVTLTTKEVRRISNHLIQNSQGLGNVLSRIADLYILSQPFMVQVMATEPPVINLLPGNFTLDIPASIMILTQSKNSTAETIVSMDFVASTSVGLVILGQRLICSLSLNR
    

Molecular Weight45541.07 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-8.98

Net Charge (pH 7.4) -9.67

Charge Density (pH 7.0) -0.0220

GRAVY Index0.20

Hydrophobic Moment 0.77

Boman Index0.18

Instability Index40.00

Aliphatic Index 104.40

Aromaticity 0.1051

Extinction Coeff. Reduced 36330.00

Extinction Coeff. Oxidized 36580.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382390 VERIFIED: NO

Provenance & Taxonomy

OrganismCamelus dromedarius [Animal]

FamilyBPI

Tax ID9838

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence