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MYP_098854
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Basic Information
Defensin beta 118 (Beta-defensin 18) (DEFB-18) (Epididymal secretory protein 13.6) (ESP13.6)
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
123 amino acids
C587H954N168O185S9
Standard
Sequence
MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS
Physicochemical Analysis
13613.45 Da
6.88
-0.19
-0.73
-0.0015
-0.44
0.64
-0.08
51.66
77.64
0.0407
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
5653.03
-63.07
201.0
198.0
450.0
949.0
19.0
128.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064532 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11564719;12600824;11780052;15489334;11854508;15033915;33224970;33181266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11564719/
RECORD: Rec_0233153 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear polypeptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Non-hemolytic
Qualitative functional evidence
Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11181995/
RECORD: Rec_0233713 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. typhimurium
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11564719;12600824;11780052;15489334;11854508;15033915;33224970;33181266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11564719/
RECORD: Rec_0333510 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Bacillus subtilis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11564719;12600824;11780052;15489334;11854508;15033915;33224970;33181266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11564719/
RECORD: Rec_0385256 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11564719;12600824;11780052;15489334;11854508;15033915;33224970;33181266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11564719/