Peptide Database

Peptide NameSLAY-screened peptide P735

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC96H157N33O29S

DescriptionStandard

        SVRNGTIAPCVSRPSAWRPTN
    

Molecular Weight2269.54 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)2.45

Net Charge (pH 7.4) 2.23

Charge Density (pH 7.0) 0.1167

GRAVY Index-0.54

Hydrophobic Moment 0.40

Boman Index-0.15

Instability Index35.72

Aliphatic Index 55.71

Aromaticity 0.0476

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1007.77

LogP -14.42

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 66.0

Heavy Atoms 159.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064885 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/