Peptide Database

Peptide NametagT signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC199H340N60O48S2

DescriptionStandard

        MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYA
    

Molecular Weight4405.33 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)8.50

Net Charge (pH 7.4) 8.27

Charge Density (pH 7.0) 0.2179

GRAVY Index-0.17

Hydrophobic Moment 0.78

Boman Index-0.12

Instability Index52.79

Aliphatic Index 92.56

Aromaticity 0.0769

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1793.03

LogP -13.34

H-bond Donors 66.0

H-bond Acceptors 59.0

Rotatable Bonds 157.0

Heavy Atoms 309.0

Ring Count 4.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221715 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Cutinase secretion

TargetBacillus subtilis TEB1030

Activity0.0 U/mL

MethodCutinase activity assay

PaperBrockmeier U, Caspers M, Freudl R, et al. Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria[J]. Journal of Molecular Biology, 2006, 362(3): 393-402. PMID16930615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16930615/

RECORD: Rec_0387865 VERIFIED: YES