Peptide Database

Peptide NameyccK signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC115H202N36O32S

DescriptionStandard

        MDQTRTLGKTKLKVKRIGFGANAV
    

Molecular Weight2633.12 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)4.50

Net Charge (pH 7.4) 4.28

Charge Density (pH 7.0) 0.1874

GRAVY Index-0.40

Hydrophobic Moment 0.44

Boman Index-0.15

Instability Index4.28

Aliphatic Index 81.25

Aromaticity 0.0417

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1144.67

LogP -12.27

H-bond Donors 41.0

H-bond Acceptors 38.0

Rotatable Bonds 94.0

Heavy Atoms 184.0

Ring Count 1.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399976 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis subsp. subtilis str. 168 [Bacterium]

FamilyTat signal peptide

Tax ID224308

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity5638.0 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/