Peptide Database

Peptide NameHuwentoxin-IV

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Venom / Toxin ▸ General toxin ▸ huwentoxin-1 family

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC174H283N51O52S6

DescriptionStandard

        ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI
    

Molecular Weight4113.81 Da

Isoelectric Point (pI)8.89

Net Charge (pH 7.0)3.78

Net Charge (pH 7.4) 3.51

Charge Density (pH 7.0) 0.1079

GRAVY Index-0.58

Hydrophobic Moment 0.40

Boman Index-0.24

Instability Index69.01

Aliphatic Index 55.71

Aromaticity 0.0857

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1719.26

LogP -19.25

H-bond Donors 66.0

H-bond Acceptors 62.0

Rotatable Bonds 140.0

Heavy Atoms 283.0

Ring Count 5.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086983 VERIFIED: NO

Provenance & Taxonomy

OrganismSelenocosmia huwena [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-17; 9-24; 16-31

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0372477 VERIFIED: YES

Provenance & Taxonomy

OrganismHaplopelma schmidti [Animal]

Familyhuwentoxin-1 family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide2-17; 9-24; 16-31

Bio-Activity Profile

Function

Toxin Venom huwentoxin-1 family Ion channel inhibitor Pathogenesis-associated