Peptide Database

Peptide NameNaD1 (1-29)-NaD2 (30-33)-NaD1 (34-47)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC218H368N66O65S8

DescriptionStandard

        RECKTESNTFPGICITKPPCRKACISEKFSGGDCSKILRRCLCTKPC
    

Molecular Weight5210.18 Da

Isoelectric Point (pI)9.08

Net Charge (pH 7.0)5.68

Net Charge (pH 7.4) 5.35

Charge Density (pH 7.0) 0.1209

GRAVY Index-0.41

Hydrophobic Moment 0.65

Boman Index-0.19

Instability Index73.81

Aliphatic Index 51.91

Aromaticity 0.0426

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2124.61

LogP -25.90

H-bond Donors 83.0

H-bond Acceptors 79.0

Rotatable Bonds 174.0

Heavy Atoms 357.0

Ring Count 6.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0226944 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0284985 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetHuman histiocytic lymphoma U-937 20-30% Killing

Activity10 μM

RECORD: Rec_0325332 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetFusarium oxysporum f.sp. vasinfectum

Activity0.8

MethodIC50

RECORD: Rec_0356499 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0421219 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetU-937

Activity20.0±1.4 %

MethodCytotoxicity