Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC73H122N22O29S

DescriptionStandard

        AGDDQGLDKCVPNSKEK
    

Molecular Weight1803.94 Da

Isoelectric Point (pI)4.68

Net Charge (pH 7.0)-1.21

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0712

GRAVY Index-1.39

Hydrophobic Moment 0.40

Boman Index-0.33

Instability Index11.31

Aliphatic Index 45.88

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 853.80

LogP -11.62

H-bond Donors 28.0

H-bond Acceptors 29.0

Rotatable Bonds 63.0

Heavy Atoms 125.0

Ring Count 1.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0300446 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetInfluenza A virus (A/Roma-ISS/2/08 H1N1):inhibition of viral replication in MDCK cells

Activity0.000004±0 μM

MethodEC50

RECORD: Rec_0373272 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyLactoferrin-derived

Tax ID9913;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetInfluenza A virus (Fusion); MDCK

Activity3.7e-06 μM

MethodEC50

PaperBovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. | Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F. | Pathog Glob Health. 2012 | PMID:22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/

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