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MYP_097889
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C73H122N22O29S
Standard
Sequence
AGDDQGLDKCVPNSKEK
Physicochemical Analysis
1803.94 Da
4.68
-1.21
-1.42
-0.0712
-1.39
0.40
-0.33
11.31
45.88
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
853.80
-11.62
28.0
29.0
63.0
125.0
1.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013369 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0075597 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus (A/Parma/24/09 H1N1) | MDCK cells
0.0000034±0.00000014 μM
EC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. | Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F. | Pathog Glob Health. 2012 Mar;106(1):12-9. | DOI:10.1179/2047773212Y.0000000004 | PMID:22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0101892 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Influenza A virus (A/Parma/24/09 H1N1):inhibition of viral replication in MDCK cells
0.000003±0 μM
EC50
PaperPubMed PMID: 22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0142828 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
MDCK cells
25 μM
CC50
PaperPubMed PMID: 22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0163828 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus (A/Parma/05/06 H3N2) | MDCK cells
0.0000073±0.00000065 μM
EC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. | Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F. | Pathog Glob Health. 2012 Mar;106(1):12-9. | DOI:10.1179/2047773212Y.0000000004 | PMID:22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
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