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MYP_097869
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Basic Information
Aurein-1.2 [K8A]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C68H106N14O19
Standard
Sequence
GLFDIIKAIAESF
Physicochemical Analysis
1423.65 Da
4.37
-1.24
-1.44
-0.0952
1.11
0.59
0.46
27.01
135.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
533.37
-1.98
18.0
18.0
47.0
101.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis
64 μg/mL
MIC
Fetal bovine serum: 37℃，in fetal bovine serum, 36% remaining after 6 h
PaperMigoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W. Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2. Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054. PMID:30569430 https://pubmed.ncbi.nlm.nih.gov/30569430/ PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0060210 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis PCM 2673
64 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0064736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 10231
64 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0103014 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
512 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0127953 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
No hemolytic activity at 256microg/ml
256 μg/mL
Hemolysis
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
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