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MYP_097844
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Basic Information
Antibacterial peptide PMAP-37 (Myeloid antibacterial peptide 37; pigs, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
37 amino acids
C192H320N60O56
Standard
Sequence
GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS
Physicochemical Analysis
4364.96 Da
10.24
2.77
2.55
0.0748
-0.72
0.93
-0.30
49.29
94.86
0.0811
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1951.28
-19.00
71.0
59.0
158.0
308.0
3.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0163165 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium local isolate (IC=4 μM)
PMID7737198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737198/
RECORD: Rec_0165610 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperTossi A., Scocchi M., Zanetti M., Storici P., Gennaro R.;. "PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity."; Eur. J. Biochem. 228:941-946. Evidence URLhttps://www.uniprot.org/uniprotkb/MP37_PIG/entry
RECORD: Rec_0172385 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
2 μM
MIC
PMID7737198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737198/
RECORD: Rec_0185258 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0197497 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923 or Cowan 1
32-64
MIC
PaperPMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity
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