Peptide Database

Peptide NameSLAY-predicted active peptide P3852

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC115H201N49O25

DescriptionStandard

        PHRIRRAITATRRILRWARRN
    

Molecular Weight2670.14 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.05

Net Charge (pH 7.4) 7.94

Charge Density (pH 7.0) 0.3831

GRAVY Index-1.14

Hydrophobic Moment 1.04

Boman Index-0.64

Instability Index135.69

Aliphatic Index 88.57

Aromaticity 0.0476

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1254.55

LogP -12.80

H-bond Donors 51.0

H-bond Acceptors 34.0

Rotatable Bonds 89.0

Heavy Atoms 189.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287841 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/