Peptide Database

Peptide NameInsulin-like growth factor II

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC323H508N94O102S6

DescriptionStandard

        AYRPSETLCGGELVDTLQFVCGDRGFYFSRPSSRINRRSRGIVEECCFRSCDLALLETYCATPAKSE
    

Molecular Weight7532.45 Da

Isoelectric Point (pI)6.46

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.54

Charge Density (pH 7.0) -0.0036

GRAVY Index-0.29

Hydrophobic Moment 0.82

Boman Index-0.11

Instability Index78.42

Aliphatic Index 65.52

Aromaticity 0.1045

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3183.87

LogP -36.66

H-bond Donors 121.0

H-bond Acceptors 108.0

Rotatable Bonds 245.0

Heavy Atoms 525.0

Ring Count 10.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0095782 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyInsulin-like growth factor

Tax ID9913

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0347162 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyInsulin

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0369555 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyInsulin-like growth factor

Tax ID9913

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetglucose metabolism in adipose tissue

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour