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MYP_097770
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Maturation inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
14 amino acids
C59H102N16O23S2
Standard
Sequence
AEAMSQVTNTATIM
Physicochemical Analysis
1467.66 Da
4.05
-1.20
-1.39
-0.0858
0.32
0.41
0.21
26.18
70.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
646.02
-8.89
22.0
24.0
48.0
100.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0090025 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 57.1%, T 21.4%, C 21.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0114274 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Maturation inhibitor Protease inhibition
CEM/LAV-1
10 μM
IC50
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0132114 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0163191 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibition
10 μM
IC50
PaperThe p2 Peptide, AEAMSQVTNTATIM, Processed from HIV-1 Pr55gag Was Found to Be a Suicide Inhibitor of HIV-1 Protease. PMID9425262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9425262/
RECORD: Rec_0254385 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
HIV | CEM/LAV-1 cells
10 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. | Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S. | J Biochem. 2004 Mar;135(3):447-53. | DOI:10.1093/jb/mvh052 | PMID:15113844 PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
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