Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length188 amino acids

Chemical FormulaC941H1507N267O249S10

DescriptionStandard

        PMALATVHEPMLLLAITEFVANSAAFTYFTAGALERNISSDMLPRRFPLQLKTKSMGLFSPQLQERYPDHPMELRLSARRQPRLSCRPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPIITRNRLGGTPCLRRGPLCLPRTGLRGLSIPQVKRLENLLKFALWLFGVPWANSECCPHPVP
    

Molecular Weight20865.32 Da

Isoelectric Point (pI)10.15

Net Charge (pH 7.0)10.28

Net Charge (pH 7.4) 9.92

Charge Density (pH 7.0) 0.0547

GRAVY Index0.03

Hydrophobic Moment 0.69

Boman Index0.06

Instability Index55.31

Aliphatic Index 96.06

Aromaticity 0.0745

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8125.78

LogP -94.67

H-bond Donors 285.0

H-bond Acceptors 273.0

Rotatable Bonds 663.0

Heavy Atoms 1467.0

Ring Count 40.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0226233 VERIFIED: NO

Provenance & Taxonomy

OrganismChroicocephalus maculipennis (Brown-hooded gull) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria