Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2246H3556N566O642S19

DescriptionStandard

        MSPCCWLALLALVPLALATNPGVKVKLTEKGIEYGKQIGMVSLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPNSGLALVPGTGISLSITNAFISLHGNWKIQYLSFIKDSGSFDLEVNGLTITDSITIKSDETGRPTVSSVNCGANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGISAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPGMMMKLLVKTVKEPTIFFEPNNVTVQASGTVTAYAIQPNTTLSPLFVLSMEGSVSARLYVTGVKLAGAVTLNKHRIGGKTHSLFHATNIYHLQYLLHYKVCMCPIFDKLVLLFSLQDYMVIGTDVQFTG
    

Molecular Weight49368.90 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)9.23

Net Charge (pH 7.4) 8.37

Charge Density (pH 7.0) 0.0203

GRAVY Index0.20

Hydrophobic Moment 0.70

Boman Index0.19

Instability Index30.04

Aliphatic Index 99.41

Aromaticity 0.0901

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 42205.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0321395 VERIFIED: NO

Provenance & Taxonomy

OrganismHucho hucho [Bacterium]

FamilyBPI

Tax ID62062

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence