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MYP_097430
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Basic Information
Caerin 1.1GG
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C115H194N32O30
Standard
Sequence
GLLSVLGSVAKHVLGHVVGVIAEHL
Physicochemical Analysis
2504.97 Da
7.02
0.02
-0.33
0.0009
1.28
0.47
0.50
3.19
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
951.54
-6.31
33.0
33.0
82.0
177.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301182 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Micrococcus luteus
12.5 μg/mL
MIC
PaperThe solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.
RECORD: Rec_0310048 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
P. multocida
25-50 μg/mL
MIC
PMID9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9266696/
RECORD: Rec_0346559 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0363688 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
100 μg/mL
MIC
PMID9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9266696/
RECORD: Rec_0402313 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
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