Peptide Database

Peptide NameSK-29

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC157H268N48O43

DescriptionStandard

        SKEKIGKEFKRIVQRIKDFLRNLVPRTES
    

Molecular Weight3516.10 Da

Isoelectric Point (pI)10.53

Net Charge (pH 7.0)4.46

Net Charge (pH 7.4) 4.24

Charge Density (pH 7.0) 0.1540

GRAVY Index-0.96

Hydrophobic Moment 0.97

Boman Index-0.39

Instability Index29.62

Aliphatic Index 87.24

Aromaticity 0.0690

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1543.10

LogP -13.59

H-bond Donors 55.0

H-bond Acceptors 48.0

Rotatable Bonds 127.0

Heavy Atoms 248.0

Ring Count 3.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034053 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Immunomodulatory

Targetory activity as well as IL-8 release from neutrophils. Recombinant production:bacteria:Escherichia coli: a bacterial expression system has been established for this peptide (Li etal., 2007).

RECORD: Rec_0048791 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0107725 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStreptococcus pneumoniae

Activity250 μg/mL

MethodMIC

RECORD: Rec_0409388 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 25923

Activity2000 μg/mL

MethodMIC