Peptide Database

Peptide NameSLAY-screened peptide P1600

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H172N30O24S

DescriptionStandard

        HSIHIRVVSPWICIHLALSL
    

Molecular Weight2294.76 Da

Isoelectric Point (pI)8.28

Net Charge (pH 7.0)1.01

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0506

GRAVY Index1.16

Hydrophobic Moment 0.40

Boman Index0.42

Instability Index64.34

Aliphatic Index 170.50

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 831.85

LogP -3.44

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 70.0

Heavy Atoms 162.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020697 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/