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MYP_097387
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Basic Information
peptide derived from bovine alphaS1-casein (194-199)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
6 amino acids
C35H53N7O9S
Standard
Sequence
TTMPLW
Physicochemical Analysis
747.90 Da
5.18
-0.60
-0.79
-0.1003
0.30
0.15
0.42
121.03
65.00
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
256.28
-0.39
9.0
10.0
19.0
52.0
3.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0370040 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
ACE-inhibitory peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
16 μM
IC50
PaperAntihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk
RECORD: Rec_0389517 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
12 μM
IC50
PaperIntegration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity
RECORD: Rec_0399039 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
12 μM
IC50
PaperAngiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine αS2-casein | Tauzin, J. et al. | DOI: 10.1016/s0014-5793(02)03576-7 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0410267 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
13.6 mmHg
SBP decrease
PaperAntihypertensive peptides: production, bioavailability and incorporation into foods. PMID21185549 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185549/
RECORD: Rec_0411649 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Micrococcus luteus ATCC 49732
64 μM
MIC
PMID24176365 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176365/
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